TFEB monoclonal antibody (M01), clone S1
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More Files
- More Functions
Western Blot (Tissue lysate)
TFEB monoclonal antibody (M01), clone S1. Western Blot analysis of TFEB expression in rat brain.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TFEB is approximately 0.03ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to TFEB on HeLa cell. [antibody concentration 20 ug/ml]
Western Blot detection against Immunogen (78.1 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant TFEB.
Immunogen
TFEB (AAH32448, 1 a.a. ~ 476 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL
Host
Mouse
Reactivity
Human, Rat
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (78.1 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
TFEB monoclonal antibody (M01), clone S1. Western Blot analysis of TFEB expression in rat brain.Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TFEB is approximately 0.03ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to TFEB on HeLa cell. [antibody concentration 20 ug/ml] -
Gene Info — TFEB
Entrez GeneID
7942GeneBank Accession#
BC032448Protein Accession#
AAH32448Gene Name
TFEB
Gene Alias
AlphaTFEB, TCFEB, bHLHe35
Gene Description
transcription factor EB
Omim ID
600744Gene Ontology
HyperlinkOther Designations
OTTHUMP00000043540|OTTHUMP00000043542|OTTHUMP00000071327|T-cell transcription factor EB
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Interactome
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Publication Reference
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TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
Hongjie Wang, Mohan Kumar Muthu Karuppan, Dinesh Devadoss, Madhavan Nair, Hitendra S Chand, Madepalli Krishnappa Lakshmana.
Neurobiology of Aging 2021 Oct; 106:26.
Application：WB-Ti, Mouse, Mouse brain.
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Proteomic Profiling of Iron-Treated Ovarian Cells Identifies AKT Activation, which Modulates the CLEAR Network.
Rockfield S, Guergues J, Rehman N, Smith A, Bauckman KA, Stevens SM Jr, Nanjundan M.
Proteomics 2018 Sep; e1800244.
Application：IF, Human, HEY cells.
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Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains.
Wang H, Wang R, Xu S, Lakshmana MK.
Neuroscience Journal 2016 Jun; 2016:4732837.
Application：WB-Ti, Human, Brain.
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TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory deficits.
Wang H, Wang R, Carrera I, Xu S, Lakshmana MK.
eNeuro 2016 May; 3(2):e0042-16.2.
Application：WB-Ti, Mouse, Cortex, Hippocampus, Thalamus, Brainstem, Cerebellum.
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Neuraminidase of influenza A virus binds LAMPs directly and induces lysosome rupture.
Ju X, Yan Y, Liu Q, Li N, Sheng M, Zhang L, Li X, Liang Z, Huang F, Liu K, Zhao Y, Zhang Y, Zou Z, Du J, Zhong Y, Zhou H, Yang P, Lu H, Tian M, Li D, Zhang J, Jin N, Jiang C.
Journal of Virology 2015 Oct; 89(20):10347.
Application：Immunoblot, Human, A549 cells.
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TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
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