Western blot analysis of RNF103 over-expressed 293 cell line, cotransfected with RNF103 Validated Chimera RNAi ( Cat # H00007844-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with RNF103 monoclonal antibody (M01), clone 3E7 (Cat # H00007844-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. [provided by RefSeq
Zinc finger protein expressed in cerebellum,zinc finger protein 103 homolog