PXDN monoclonal antibody (M03), clone 2C11
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PXDN.
Immunogen
PXDN (XP_056455, 1452 a.a. ~ 1561 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
STSAFSTRSDASGTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEK
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PXDN is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — PXDN
Entrez GeneID
7837GeneBank Accession#
XM_056455Protein Accession#
XP_056455Gene Name
PXDN
Gene Alias
D2S448, D2S448E, KIAA0230, MG50, PRG2, PXN, VPO
Gene Description
peroxidasin homolog (Drosophila)
Omim ID
605158Gene Ontology
HyperlinkGene Summary
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM
Other Designations
p53-responsive gene 2|peroxidasin homolog
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Interactome
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Disease
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