DNALI1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specifications
Product Description
Mouse polyclonal antibody raised against a full-length human DNALI1 protein.
Immunogen
DNALI1 (AAH46117.1, 1 a.a. ~ 258 a.a) full-length human protein.
Sequence
MIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (97)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DNALI1 expression in transfected 293T cell line (H00007802-T02) by DNALI1 MaxPab polyclonal antibody.
Lane 1: DNALI1 transfected lysate(28.38 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to DNALI1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — DNALI1
Entrez GeneID
7802GeneBank Accession#
BC046117.1Protein Accession#
AAH46117.1Gene Name
DNALI1
Gene Alias
P28, dJ423B22.5, hp28
Gene Description
dynein, axonemal, light intermediate chain 1
Omim ID
602135Gene Ontology
HyperlinkGene Summary
This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq
Other Designations
OTTHUMP00000004400|dJ423B22.5 (axonemal dynein light chain (hp28))|dynein, axonemal, light intermediate polypeptide 1|inner dynein arm, homolog of clamydomonas
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Interactomes
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Diseases
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Publication Reference
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DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.
Huan Wu, Yiyuan Liu, Yuqian Li, Kuokuo Li, Chuan Xu, Yang Gao, Mingrong Lv, Rui Guo, Yuping Xu, Ping Zhou, Zhaolian Wei, Rong Hua, Xiaojin He, Yunxia Cao.
Cell Death & Disease 2023 Feb; 14(2):127.
Application:IF, WB-Ti, Human, Mouse, Human semen, Mouse semen.
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DNAH17 is associated with asthenozoospermia and multiple morphological abnormalities of sperm flagella.
Sha Y, Wei X, Ding L, Mei L, Huang X, Lin S, Su Z, Kong L, Zhang Y, Ji Z.
Annals of Human Genetics 2019 Dec; [Epub].
Application:IF, Human, Human spermatozoa .
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Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.
Ryan R, Failler M, Reilly ML, Garfa-Traore M, Delous M, Filhol E, Reboul T, Bole-Feysot C, Nitschké P, Baudouin V, Amselem S, Escudier E, Legendre M, Benmerah A, Saunier S.
Human Molecular Genetics 2018 Jan; 27(2):266.
Application:IF, Human, Ciliated cells.
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DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.
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