TRIM25 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Western Blot (Cell lysate)
TRIM25 MaxPab polyclonal antibody. Western Blot analysis of TRIM25 expression in Hela S3 NE.
Western Blot (Transfected lysate)
Western Blot analysis of TRIM25 expression in transfected 293T cell line (H00007706-T01) by TRIM25 MaxPab polyclonal antibody.
Lane 1: TRIM25 transfected lysate(69.3 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to TRIM25 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human TRIM25 protein.
Immunogen
TRIM25 (AAH16924.1, 1 a.a. ~ 630 a.a) full-length human protein.
Sequence
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLVEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTPSSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPESRLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAFWVFSAGATLSICSPK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73); Rat (71)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
TRIM25 MaxPab polyclonal antibody. Western Blot analysis of TRIM25 expression in Hela S3 NE.Western Blot (Transfected lysate)
Western Blot analysis of TRIM25 expression in transfected 293T cell line (H00007706-T01) by TRIM25 MaxPab polyclonal antibody.
Lane 1: TRIM25 transfected lysate(69.3 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to TRIM25 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — TRIM25
Entrez GeneID
7706GeneBank Accession#
BC016924.1Protein Accession#
AAH16924.1Gene Name
TRIM25
Gene Alias
EFP, RNF147, Z147, ZNF147
Gene Description
tripartite motif-containing 25
Omim ID
600453Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq
Other Designations
estrogen-responsive finger protein|tripartite motif protein TRIM25|zinc finger protein 147 (estrogen-responsive finger protein)|zinc finger protein-147
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Interactome
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Disease
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Publication Reference
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Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C pro.
Huimin Xiao, Jingliang Li, Xu Yang, Zhaolong Li, Ying Wang, Yajuan Rui, Bin Liu, Wenyan Zhang.
Virologica Sinica 2021 Jun; 1.
Application：WB-Tr, Human, HEK 293T cells.
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TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, Yu J, Zhao Z, Yu XF, Zheng B, Zhang W.
EMBO reports 2020 Jan; 21(1):e47528.
Application：IP, WB-Tr, Human, RD cells.
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Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C pro.
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