XRCC4 DNAxPab
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human XRCC4 DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — XRCC4
Entrez GeneID
7518GeneBank Accession#
NM_022406.1Protein Accession#
NP_071801.1Gene Name
XRCC4
Gene Alias
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Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 4
Omim ID
194363Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq
Other Designations
DNA repair protein XRCC4|X-ray repair cross complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
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Interactome
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Pathway
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Disease
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