Immunoprecipitation of XRCC4 transfected lysate using anti-XRCC4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with XRCC4 MaxPab mouse polyclonal antibody (B01) (H00007518-B01).
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq
DNA repair protein XRCC4,X-ray repair cross complementing protein 4,X-ray repair, complementing defective, repair in Chinese hamster