XRCC4 MaxPab mouse polyclonal antibody (B01)
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More Files
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Specifications
Product Description
Mouse polyclonal antibody raised against a full-length human XRCC4 protein.
Immunogen
XRCC4 (NP_071801.1, 1 a.a. ~ 336 a.a) full-length human protein.
Sequence
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (74); Rat (70)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of XRCC4 expression in transfected 293T cell line (H00007518-T01) by XRCC4 MaxPab polyclonal antibody.
Lane 1: XRCC4 transfected lysate(36.96 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to XRCC4 on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 3 ug/ml]Immunofluorescence
Immunofluorescence of purified MaxPab antibody to XRCC4 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — XRCC4
Entrez GeneID
7518GeneBank Accession#
NM_022406.1Protein Accession#
NP_071801.1Gene Name
XRCC4
Gene Alias
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Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 4
Omim ID
194363Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq
Other Designations
DNA repair protein XRCC4|X-ray repair cross complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
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Interactomes
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Pathways
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Diseases
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Publication Reference
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A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
Enervald E, Du L, Visnes T, Bjorkman A, Lindgren E, Wincent J, Borck G, Colleaux L, Cormier-Daire V, van Gent DC, Pie J, Puisac B, de Miranda NF, Kracker S, Hammarstrom L, de Villartay JP, Durandy A, Schoumans J, Strom L, Pan-Hammarstrom Q.
The Journal of Experimental Medicine 2013 Nov; 210(12):2503.
Application:WB-Tr, Human, Fibroblast cells.
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A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
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