XRCC1 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human XRCC1 full-length ORF ( AAH23593.1, 1 a.a. - 633 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGGLEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
95.37
Interspecies Antigen Sequence
Mouse (86)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — XRCC1
Entrez GeneID
7515GeneBank Accession#
BC023593Protein Accession#
AAH23593.1Gene Name
XRCC1
Gene Alias
RCC
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 1
Omim ID
194360Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
Other Designations
DNA repair protein XRCC1|X-ray repair cross complementing protein 1|X-ray-repair, complementing defective, repair in Chinese hamster
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Interactome
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Pathway
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Disease
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Publication Reference
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Reading ADP-ribosylation signaling using chemical biology and interaction proteomics.
Katarzyna W Kliza, Qiang Liu, Laura W M Roosenboom, Pascal W T C Jansen, Dmitri V Filippov, Michiel Vermeulen.
Molecular Cell 2021 Nov; 81(21):4552.
Application:Purify, Human, Human Peptide.
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Reading ADP-ribosylation signaling using chemical biology and interaction proteomics.
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