XRCC1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human XRCC1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human XRCC1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human XRCC1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — XRCC1
Entrez GeneID
7515GeneBank Accession#
XRCC1Gene Name
XRCC1
Gene Alias
RCC
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 1
Omim ID
194360Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
Other Designations
DNA repair protein XRCC1|X-ray repair cross complementing protein 1|X-ray-repair, complementing defective, repair in Chinese hamster
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Interactome
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