WRN polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant WRN.
Immunogen
WRN (NP_000544, 1322 a.a. ~ 1432 a.a) partial recombinant protein with GST tag.
Sequence
NPPVNSDMSKISLIRMLAPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (61)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.32 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — WRN
Entrez GeneID
7486GeneBank Accession#
NM_000553Protein Accession#
NP_000544Gene Name
WRN
Gene Alias
DKFZp686C2056, RECQ3, RECQL2, RECQL3
Gene Description
Werner syndrome
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq
Other Designations
Werner Syndrome helicase|Werner syndrome protein
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Interactome
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Disease
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