WNT2B (Human) Recombinant Protein (P01)
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Specification
Product Description
Human WNT2B full-length ORF ( NP_078613.1, 1 a.a. - 391 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MLRPGGAEEAAQLPLRRASAPVPVPSPAAPDGSRASARLGLACLLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
70.2
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — WNT2B
Entrez GeneID
7482GeneBank Accession#
NM_024494.1Protein Accession#
NP_078613.1Gene Name
WNT2B
Gene Alias
WNT13, XWNT2
Gene Description
wingless-type MMTV integration site family, member 2B
Omim ID
601968Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000012856|OTTHUMP00000012857|XWNT2, Xenopus, homolog of|wingless-type MMTV integration site family, member 13
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Interactome
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Pathway
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Disease
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Publication Reference
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Teriflunomide Promotes Blood-Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis.
Yipeng Zhao, Chen Chen, Xiuqing Xiao, Ling Fang, Xi Cheng, Yanyu Chang, Fuhua Peng, Jingqi Wang, Shishi Shen, Shilin Wu, Yiying Huang, Wei Cai, Linli Zhou, Wei Qiu.
Molecular Neurobiology 2023 Oct; [Epub]:0.
Application：Stimulation, Human, Human brain microvascular endothelial cells.
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Teriflunomide Promotes Blood-Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis.
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