WNT2 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human WNT2 full-length ORF ( AAH29854, 1 a.a. - 360 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MNAPLGGIWLWLPLLLTWLTPEVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTAT
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
65.34
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — WNT2
Entrez GeneID
7472GeneBank Accession#
BC029854Protein Accession#
AAH29854Gene Name
WNT2
Gene Alias
INT1L1, IRP
Gene Description
wingless-type MMTV integration site family member 2
Omim ID
147870Gene Ontology
HyperlinkGene Summary
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq
Other Designations
Int-1-related protein|protein Wnt-2|secreted growth factor
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Interactome
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Pathway
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Disease
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Publication Reference
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WNT Co-Receptor LRP6 Is Critical for Zygotic Genome Activation and Embryonic Developmental Potential by Interacting with Oviductal Paracrine Ligand WNT2.
Fusheng Yao, Jia Hao, Zhaochen Wang, Meiqiang Chu, Jingyu Zhang, Guangyin Xi, Zhenni Zhang, Lei An, Jianhui Tian.
Genes 2023 Apr; 14(4):891.
Application:Sub, Mouse, Mouse embryo.
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Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion.
Zhang Z, Wang J, Dong X.
Oncology Letters 2018 Sep; 16(3):2857.
Application:Func, Human, BGC823, SGC-790 cells.
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Decreased expression of WNT2 in villi of unexplained recurrent spontaneous abortion patients may cause trophoblast cell dysfunction via downregulated Wnt/β-catenin signaling pathway.
Li N, Li S, Wang Y, Wang J, Wang K, Liu X, Li Y, Liu J.
Cell Biology International 2017 Aug; 41(8):898.
Application:Func, Human, HTR-8/SVneo cells.
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Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening.
Tsaousi A, Williams H, Lyon CA, Taylor V, Swain A, Johnson JL, George SJ.
Circulation Research 2011 Feb; 108(4):427.
Application:Treated, Recombinant protein.
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Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation and late embryonic lethality.
Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K.
The Journal of Biological Chemistry 2007 Apr; 282(21):15578.
Application:Func, Sensor chips.
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WNT Co-Receptor LRP6 Is Critical for Zygotic Genome Activation and Embryonic Developmental Potential by Interacting with Oviductal Paracrine Ligand WNT2.
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