WHSC1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human WHSC1 protein.
Immunogen
WHSC1 (NP_579889.1, 1 a.a. ~ 647 a.a) full-length human protein.
Sequence
MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENELLWEPTPVKLDLNPAALYCT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (86); Rat (85)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of WHSC1 expression in transfected 293T cell line (H00007468-T01) by WHSC1 MaxPab polyclonal antibody.
Lane1:WHSC1 transfected lysate(71.17 KDa).
Lane2:Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to WHSC1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — WHSC1
Entrez GeneID
7468GeneBank Accession#
NM_133334.2Protein Accession#
NP_579889.1Gene Name
WHSC1
Gene Alias
FLJ23286, KIAA1090, MGC176638, MMSET, NSD2, REIIBP, TRX5, WHS
Gene Description
Wolf-Hirschhorn syndrome candidate 1
Omim ID
602952Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq
Other Designations
IL5 promoter REII region-binding protein|OTTHUMP00000149955|OTTHUMP00000159146|Wolf-Hirschhorn syndrome candidate 1 protein|multiple myeloma SET domain containing protein type III|trithorax/ash1-related protein 5
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Interactome
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Disease
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Publication Reference
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Markers for Acute Lymphoblastic Leukemia.
Chan HM, Englund NP, Garraway L, Hu M, Jaffe J, Kryukov G, Liu J, Liu X, Mcdonald R, Stegmeier FP, Wang Z, Wang Y, Wu H, Yan F.
Amino Acids 2015 Dec; US20150354006A1.
Application:WB, Human, DND-41, DND-412, HPB-ALL, JURKAT, LOUCY, MOLT13, MOLT16, KMS11, PF-3824, RCH-ACV, RPMI-8402, RS4-11, SEM, SUPT-11, T-ALL1 cells.
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NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.
Huang Z, Wu H, Chuai S, Xu F, Yan F, Englund N, Wang Z, Zhang H, Fang M, Wang Y, Gu J, Zhang M, Yang TY, Zhao K, Yu Y, Dai J, Yi W, Zhou S, Li Q, Wu J, Liu J, Wu X, Chan H, Lu CX, Atadja PW, Li E, Wang Y, Hu M.
Cancer Research 2013 Oct; 73(20):6277.
Application:WB-Ce, Human, U266, MOLP2, COLO677, RPMI8226, KMS27, KMS21BM, KMS12BM, KHM1B, KMS11, KMS34, LP1, H929, KMS28BM, jim3, OPM2, KMS18 cells.
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Markers for Acute Lymphoblastic Leukemia.
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