VMD2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Western Blot
Lane 1: BEST1 transfected lysate ( 69.1 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
BEST1 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-VMD2 full-length
Host
Human
Theoretical MW (kDa)
66.55
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-VMD2 antibody (H00007439-B01) by Western Blots.
Western Blot
Lane 1: BEST1 transfected lysate ( 69.1 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
BEST1 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — BEST1
Entrez GeneID
7439GeneBank Accession#
BC041664.1Protein Accession#
-Gene Name
BEST1
Gene Alias
ARB, BEST, BMD, TU15B, VMD2
Gene Description
bestrophin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms
Other Designations
Best disease|vitelliform macular dystrophy protein 2
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Interactome
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Disease
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