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VHL 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00007428-T02
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-VHL full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 19.7
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-VHL antibody (H00007428-D01P)byWesternBlots.
    SDS-PAGE Gel
    QC Testing of H00007428-T02
    VHL transfected lysate.
    Western Blot
    QC Testing of H00007428-T02
    Lane 1: VHL transfected lysate ( 19.7 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 7428
  • Gene Name:
  • VHL
  • Gene Alias:
  • Gene Description:
  • von Hippel-Lindau tumor suppressor
  • Gene Summary:
  • Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • elongin binding protein
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