VHL purified MaxPab rabbit polyclonal antibody (D01P)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human VHL protein.
Immunogen
VHL (ENSP00000344757, 1 a.a. ~ 172 a.a) full-length human protein.
Sequence
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (63); Rat (63)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
-
Applications
Western Blot (Tissue lysate)
VHL MaxPab rabbit polyclonal antibody. Western Blot analysis of VHL expression in mouse lung.Western Blot (Transfected lysate)
Western Blot analysis of VHL expression in transfected 293T cell line (H00007428-T02) by VHL MaxPab polyclonal antibody.
Lane 1: VHL transfected lysate(19.70 KDa).
Lane 2: Non-transfected lysate.
-
Gene Info — VHL
Entrez GeneID
7428GeneBank Accession#
NM_198156Protein Accession#
ENSP00000344757Gene Name
VHL
Gene Alias
HRCA1, RCA1, VHL1
Gene Description
von Hippel-Lindau tumor suppressor
Gene Ontology
HyperlinkGene Summary
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
elongin binding protein
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com