VCP monoclonal antibody (M03), clone 4A8
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More Files
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Western Blot (Cell lysate)
VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in PC-12.
Western Blot (Cell lysate)
VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in Raw 264.7.
Western Blot (Cell lysate)
VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in Hela S3 NE.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to VCP on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged VCP is 1 ng/ml as a capture antibody.
Western Blot detection against Immunogen (90.42 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant VCP.
Immunogen
VCP (AAH07562, 1 a.a. ~ 588 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG
Host
Mouse
Reactivity
Human, Mouse, Rat
Interspecies Antigen Sequence
Mouse (100); Rat (99)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (90.42 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in PC-12.Western Blot (Cell lysate)
VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in Raw 264.7.Western Blot (Cell lysate)
VCP monoclonal antibody (M03), clone 4A8. Western Blot analysis of VCP expression in Hela S3 NE.Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to VCP on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged VCP is 1 ng/ml as a capture antibody.ELISA
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Gene Info — VCP
Entrez GeneID
7415GeneBank Accession#
BC007562Protein Accession#
AAH07562Gene Name
VCP
Gene Alias
IBMPFD, MGC131997, MGC148092, MGC8560, TERA, p97
Gene Description
valosin-containing protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq
Other Designations
transitional endoplasmic reticulum ATPase|yeast Cdc48p homolog
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Interactome
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Disease
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Publication Reference
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PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation.
You X, Xu DD, Zhang D, Chen J, Gao FG.
Journal of Immunology Research 2018 Jul; 2018:5070573.
Application：IF, Mouse, Mouse bone marrow derived-dendritic cells.
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Deciphering the Molecular Mechanism Underlying the Inhibitory Efficacy of Taiwanese Local Pomegranate Peels against Urinary Bladder Urothelial Carcinoma.
Chang CP, Chan YY, Li CF, Chien LH, Lee ST, Wu TF.
Nutrients 2018 Apr; 10(5):E543.
Application：WB, Human, T24 cells.
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PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation.
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