VAV1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human VAV1 partial ORF ( AAH13361, 681 a.a. - 790 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
RGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — VAV1
Entrez GeneID
7409GeneBank Accession#
BC013361Protein Accession#
AAH13361Gene Name
VAV1
Gene Alias
VAV
Gene Description
vav 1 guanine nucleotide exchange factor
Omim ID
164875Gene Ontology
HyperlinkGene Summary
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Other Designations
oncogene vav|vav 1 oncogene|vav proto-oncogene
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Interactome
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Pathway
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