VAV1 monoclonal antibody (M01), clone 9C1
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant VAV1.
Immunogen
VAV1 (AAH13361, 681 a.a. ~ 790 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
VAV1 monoclonal antibody (M01), clone 9C1 Western Blot analysis of VAV1 expression in Jurkat ( Cat # L017V1 ).Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to VAV1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — VAV1
Entrez GeneID
7409GeneBank Accession#
BC013361Protein Accession#
AAH13361Gene Name
VAV1
Gene Alias
VAV
Gene Description
vav 1 guanine nucleotide exchange factor
Omim ID
164875Gene Ontology
HyperlinkGene Summary
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Other Designations
oncogene vav|vav 1 oncogene|vav proto-oncogene
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Interactome
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Pathway
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Publication Reference
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Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation.
Laufer JM, Hauser MA, Kindinger I, Purvanov V, Pauli A, Legler DF.
Cell Reports 2019 Oct; 29(4):995.
Application:PLA-Ce, Human, Mature monocyte-derived dendritic cells.
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Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation.
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