UTRN monoclonal antibody (M01), clone 5G6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant UTRN.
Immunogen
UTRN (NP_009055, 3328 a.a. ~ 3433 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASPQHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFPSCCPNVPSRPQAM
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (92)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.4 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged UTRN is 0.1 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to UTRN on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — UTRN
Entrez GeneID
7402GeneBank Accession#
NM_007124Protein Accession#
NP_009055Gene Name
UTRN
Gene Alias
DMDL, DRP, DRP1, FLJ23678
Gene Description
utrophin
Omim ID
128240Gene Ontology
HyperlinkGene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq
Other Designations
OTTHUMP00000017350|OTTHUMP00000040139|dystrophin-related protein
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Interactome
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Disease
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