Western blot analysis of USF1 over-expressed 293 cell line, cotransfected with USF1 Validated Chimera RNAi ( Cat # H00007391-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with USF1 monoclonal antibody (M01), clone 3F6 (Cat # H00007391-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
OTTHUMP00000029691,OTTHUMP00000029693,major late transcription factor 1,upstream stimulatory factor 1