UROD (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human UROD full-length ORF ( AAH01778.1, 1 a.a. - 367 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQVNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
66
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — UROD
Entrez GeneID
7389GeneBank Accession#
BC001778.1Protein Accession#
AAH01778.1Gene Name
UROD
Gene Alias
PCT
Gene Description
uroporphyrinogen decarboxylase
Omim ID
176100Gene Ontology
HyperlinkGene Summary
This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria. [provided by RefSeq
Other Designations
OTTHUMP00000010502|fifth enzyme of heme biosynthetic pathway|fifth enzyme of the heme biosynthetic pathway|uroporphyrinogen III decarboxylase
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Interactome
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Pathway
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Disease
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