UMPS monoclonal antibody (M06), clone 2B10
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant UMPS.
Immunogen
UMPS (NP_000364, 381 a.a. ~ 479 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
DYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
UMPS monoclonal antibody (M06), clone 2B10. Western Blot analysis of UMPS expression in IMR-32 ( Cat # L008V1 ).Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged UMPS is approximately 0.1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to UMPS on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — UMPS
Entrez GeneID
7372GeneBank Accession#
NM_000373Protein Accession#
NP_000364Gene Name
UMPS
Gene Alias
OPRT
Gene Description
uridine monophosphate synthetase
Omim ID
258900Gene Ontology
HyperlinkOther Designations
OMPdecase|OPRtase|UMP synthase|orotate phosphoribosyl transferase and orotidine-5'-decarboxylase|orotate phosphoribosyltransferase phosphoribosyltransferase|orotidine 5'-phosphate decarboxylase|uridine monophosphate synthase
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.
Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, Hou YC, Griffith OL, Cheng GS, Novik K, Moore R, Luk M, Owen D, Brown CJ, Morin GB, Gill S, Tai IT, Marra MA.
The Pharmacogenomics Journal 2012 Jan; 13(2):148.
Application:WB-Ce, Human, MIP101 and MIP/5FU cell lines.
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Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.
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