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Last updated: 2016/11/27

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UMOD 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00007369-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-UMOD full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 67.32
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-UMOD antibody (H00007369-B01) by Western Blots.
    Western Blot
    QC Testing of H00007369-T01
    Lane 1: UMOD transfected lysate ( 66.7 KDa)
    Lane 2: Non-transfected lysate.
    SDS-PAGE Gel
    QC Testing of H00007369-T01
    UMOD transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 7369
  • Gene Name:
  • UMOD
  • Gene Alias:
  • ADMCKD2,FJHN,HNFJ,MCKD2,THGP,THP
  • Gene Description:
  • uromodulin
  • Gene Summary:
  • This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000162212,Tamm-Horsfall glycoprotein,uromodulin (uromucoid, Tamm-Horsfall glycoprotein),uromucoid
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