UGT8 polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (38.21 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant UGT8.
Immunogen
UGT8 (NP_003351, 31 a.a. ~ 140 a.a) partial recombinant protein with GST tag.
Sequence
FESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPN
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — UGT8
Entrez GeneID
7368GeneBank Accession#
NM_003360Protein Accession#
NP_003351Gene Name
UGT8
Gene Alias
CGT
Gene Description
UDP glycosyltransferase 8
Omim ID
601291Gene Ontology
HyperlinkGene Summary
Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney. The key enzymatic step in the biosynthesis of galactocerebrosides consists of the transfer of galactose to ceramide catalyzed by UDP-galactose ceramide galactosyltransferase (CGT, EC 2.4.1.45). The enzyme encoded by the CGT gene is the first involved in complex lipid biosynthesis in the myelinating oligodendrocyte.[supplied by OMIM
Other Designations
UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)|UDP-galactose ceramide galactosyltransferase
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Interactome
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Pathway
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Disease
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Publication Reference
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Axonopathy is a compounding factor in the pathogenesis of Krabbe disease.
Castelvetri LC, Givogri MI, Zhu H, Smith B, Lopez-Rosas A, Qiu X, van Breemen R, Bongarzone ER.
Acta Neuropathologica 2011 Jul; 122(1):35.
Application：WB-Ti, Mouse, Mouse spinal cords, NSC34 cells.
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Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides.
Zhang X, Nakajima T, Kamijo Y, Li G, Hu R, Kannagi R, Kyogashima M, Aoyama T, Hara A.
Biochemical and Biophysical Research Communications 2009 Dec; 390(4):1382.
Application：WB, Mouse, Liver, Kidney.
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Axonopathy is a compounding factor in the pathogenesis of Krabbe disease.
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