UGT2B7 monoclonal antibody (M02), clone 8D12
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant UGT2B7.
Immunogen
UGT2B7 (NP_001065, 69 a.a. ~ 157 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCS
Host
Mouse
Reactivity
Human, Rat
Interspecies Antigen Sequence
Mouse (42); Rat (44)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.53 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
UGT2B7 monoclonal antibody (M02), clone 8D12. Western Blot analysis of UGT2B7 expression in PC-12.Western Blot (Transfected lysate)
Western Blot analysis of UGT2B7 expression in transfected 293T cell line by UGT2B7 monoclonal antibody (M02), clone 8D12.
Lane 1: UGT2B7 transfected lysate (Predicted MW: 58.19 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged UGT2B7 is 0.1 ng/ml as a capture antibody.ELISA
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Gene Info — UGT2B7
Entrez GeneID
7364GeneBank Accession#
NM_001074Protein Accession#
NP_001065Gene Name
UGT2B7
Gene Alias
UGT2B9
Gene Description
UDP glucuronosyltransferase 2 family, polypeptide B7
Omim ID
600068Gene Ontology
HyperlinkGene Summary
The UGTs (EC 2.4.1.17) serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Its subcellular location is the microsome.[supplied by OMIM
Other Designations
UDP glycosyltransferase 2 family, polypeptide B7|UDP-glucuronosyltransferase 2B7|UDP-glucuronyltransferase, family 2, beta-7
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Interactome
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Pathway
- Androgen and estrogen metabolism
- Ascorbate and aldarate metabolism
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Metabolic pathways
- Metabolism of xenobiotics by cytochrome P450
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Retinol metabolism
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