Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

UBE2V1

Gene Alias

CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A

Gene Description

ubiquitin-conjugating enzyme E2 variant 1

Omim ID

Gene Ontology

Gene Summary

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq

Other Designations

DNA-binding protein|OTTHUMP00000031795|OTTHUMP00000031796|OTTHUMP00000039980