TYROBP (Human) Recombinant Protein (Q01)
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More Files
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Specifications
Product Description
Human TYROBP partial ORF ( AAH11175, 21 a.a. - 113 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.97
Interspecies Antigen Sequence
Mouse (76); Rat (75)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TYROBP
Entrez GeneID
7305GeneBank Accession#
BC011175Protein Accession#
AAH11175Gene Name
TYROBP
Gene Alias
DAP12, KARAP, PLOSL
Gene Description
TYRO protein tyrosine kinase binding protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. [provided by RefSeq
Other Designations
DNAX-activation protein 12|killer activating receptor associated protein
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Interactomes
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Pathways
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Diseases
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