Immunoprecipitation of TYR transfected lysate using anti-TYR MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TYR purified MaxPab mouse polyclonal antibody (B01P) (H00007299-B01P).
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq