TXNRD1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
TXNRD1 transfected lysate.
Western Blot
Lane 1: TXNRD1 transfected lysate ( 54.5 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TXNRD1 full-length
Host
Human
Theoretical MW (kDa)
54.5
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TXNRD1 antibody (H00007296-B01) by Western Blots.
SDS-PAGE Gel
TXNRD1 transfected lysate.
Western Blot
Lane 1: TXNRD1 transfected lysate ( 54.5 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TXNRD1
Entrez GeneID
7296GeneBank Accession#
NM_182729.1Protein Accession#
-Gene Name
TXNRD1
Gene Alias
GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR
Gene Description
thioredoxin reductase 1
Omim ID
601112Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq
Other Designations
KM-102-derived reductase-like factor|oxidoreductase|thioredoxin reductase GRIM-12
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Interactome
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Pathway
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Disease
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