HIRA 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
HIRA transfected lysate.
Western Blot
Lane 1: HIRA transfected lysate ( 111.8 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HIRA full-length
Host
Human
Theoretical MW (kDa)
111.8
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HIRA antibody (H00007290-B01) by Western Blots.
SDS-PAGE Gel
HIRA transfected lysate.
Western Blot
Lane 1: HIRA transfected lysate ( 111.8 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HIRA
Entrez GeneID
7290GeneBank Accession#
NM_003325.3Protein Accession#
-Gene Name
HIRA
Gene Alias
DGCR1, TUP1, TUPLE1
Gene Description
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
Omim ID
600237Gene Ontology
HyperlinkGene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq
Other Designations
DiGeorge critical region gene 1|HIR histone cell cycle regulation defective homolog A
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Interactome
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Disease
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