PHLDA2 monoclonal antibody (M01), clone 5E3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PHLDA2.
Immunogen
PHLDA2 (NP_003302, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDF
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (77); Rat (75)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PHLDA2 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — PHLDA2
Entrez GeneID
7262GeneBank Accession#
NM_003311Protein Accession#
NP_003302Gene Name
PHLDA2
Gene Alias
BRW1C, BWR1C, HLDA2, IPL, TSSC3
Gene Description
pleckstrin homology-like domain, family A, member 2
Omim ID
602131Gene Ontology
HyperlinkGene Summary
This gene is one of several genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth. [provided by RefSeq
Other Designations
imprinted in placenta and liver|p17-Beckwith-Wiedemann region 1C|pleckstrin homology-like domain family A member 2|tumor suppressing subchromosomal transferable fragment cDNA 3|tumor suppressing subtransferable candidate 3|tumor-supressing STF cDNA 3
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Interactome
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Publication Reference
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Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting.
Suzuki S, Shaw G, Kaneko-Ishino T, Ishino F, Renfree MB.
BMC Evol Biol 2011 Aug; 11:244.
Application:IHC, Tammar, Tammar yolk sac placenta.
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Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting.
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