TPSAB1 monoclonal antibody (M01), clone 2A10-B5
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More Files
- More Functions
Western Blot (Cell lysate)
TPSAB1 monoclonal antibody (M01), clone 2A10-B5. Western Blot analysis of TPSAB1 expression in K-562.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to TPSAB1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 1 ug/ml]
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TPSAB1 is approximately 0.3ng/ml as a capture antibody.
Western Blot detection against Immunogen (55.99 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TPSAB1.
Immunogen
TPSAB1 (AAH28059, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MLSLLLLALPVLASPAYAAPAPVQALQQAGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCLGPDVKDLATLRVQLREQHLYYQDQLLPVSRIIVHPQFYIIQTGADIALLELEEPVNISSRVHTVMLPPASETFPPGMPCWVTGWGDVDNDEPLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIIRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWDEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (75); Rat (73)
Isotype
IgG2a kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (55.99 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
TPSAB1 monoclonal antibody (M01), clone 2A10-B5. Western Blot analysis of TPSAB1 expression in K-562.Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to TPSAB1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 1 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TPSAB1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — TPSAB1
Entrez GeneID
7177GeneBank Accession#
BC028059Protein Accession#
AAH28059Gene Name
TPSAB1
Gene Alias
MCP7, TPS1, TPS2, TPSB1
Gene Description
tryptase alpha/beta 1
Omim ID
191080Gene Ontology
HyperlinkGene Summary
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq
Other Designations
lung tryptase|mast cell protease II|mast cell tryptase|pituitary tryptase|skin tryptase|tryptase 1|tryptase II|tryptase alpha II|tryptase beta 1|tryptase beta I|tryptase, alpha|tryptase-I|tryptase-III
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Interactome
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Disease
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