TPM1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human TPM1 full-length ORF ( NP_001018008.1, 1 a.a. - 245 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQNRRLTNELKLALNED
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
54.8
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TPM1
Entrez GeneID
7168GeneBank Accession#
NM_001018008.1Protein Accession#
NP_001018008.1Gene Name
TPM1
Gene Alias
C15orf13, CMD1Y, HTM-alpha, TMSA
Gene Description
tropomyosin 1 (alpha)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq
Other Designations
alpha tropomyosin|cardiomyopathy, hypertrophic 3|sarcomeric tropomyosin kappa|tropomyosin 1 alpha chain
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Interactome
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Pathway
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Disease
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