Western blot analysis of TGFB1I1 over-expressed 293 cell line, cotransfected with TGFB1I1 Validated Chimera RNAi ( Cat # H00007041-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TGFB1I1 monoclonal antibody (M01), clone 4B2-D8 (Cat # H00007041-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq