TGFB1 monoclonal antibody (M04), clone X1
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More Files
- More Functions
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between MMP2 and TGFB1. HeLa cells were stained with anti-MMP2 rabbit purified polyclonal 1:1200 and anti-TGFB1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TGFB1.
Immunogen
TGFB1 (NP_000651, 279 a.a. ~ 390 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between MMP2 and TGFB1. HeLa cells were stained with anti-MMP2 rabbit purified polyclonal 1:1200 and anti-TGFB1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — TGFB1
Entrez GeneID
7040GeneBank Accession#
NM_000660Protein Accession#
NP_000651Gene Name
TGFB1
Gene Alias
CED, DPD1, TGFB, TGFbeta
Gene Description
transforming growth factor, beta 1
Gene Ontology
HyperlinkGene Summary
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM
Other Designations
TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor-beta 1
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Interactome
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Pathway
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Disease
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