TFF1 monoclonal antibody (M02), clone 3H5
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TFF1.
Immunogen
TFF1 (AAH32811.1, 1 a.a. ~ 84 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDDTVRGVPWCFYPNTIDVPPEEECEF
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (34.98 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TFF1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — TFF1
Entrez GeneID
7031GeneBank Accession#
BC032811Protein Accession#
AAH32811.1Gene Name
TFF1
Gene Alias
BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
Gene Description
trefoil factor 1
Omim ID
113710Gene Ontology
HyperlinkGene Summary
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq
Other Designations
breast cancer estrogen-inducible sequence|gastrointestinal trefoil protein pS2
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Interactome
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Disease
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Publication Reference
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CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
Iorns E, Martens-de Kemp SR, Lord CJ, Ashworth A.
Carcinogenesis 2009 Oct; 30(10):1696.
Application:WB, Human, MCF-7 cells.
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CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
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