TEK monoclonal antibody (M15), clone 4G9
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More Files
- More Functions
Western Blot detection against Immunogen (39.31 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TEK.
Immunogen
TEK (NP_000450, 66 a.a. ~ 185 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
NQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQD*
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (39.31 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — TEK
Entrez GeneID
7010GeneBank Accession#
NM_000459Protein Accession#
NP_000450Gene Name
TEK
Gene Alias
CD202B, TIE-2, TIE2, VMCM, VMCM1
Gene Description
TEK tyrosine kinase, endothelial
Gene Ontology
HyperlinkGene Summary
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq
Other Designations
OTTHUMP00000021167|soluble TIE2 variant 1|soluble TIE2 variant 2
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Interactome
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Disease
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