TDO2 polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant TDO2.
Immunogen
TDO2 (NP_005642, 307 a.a. ~ 405 a.a) partial recombinant protein with GST tag.
Sequence
PFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDES
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — TDO2
Entrez GeneID
6999GeneBank Accession#
NM_005651Protein Accession#
NP_005642Gene Name
TDO2
Gene Alias
TDO, TPH2, TRPO
Gene Description
tryptophan 2,3-dioxygenase
Omim ID
191070Gene Ontology
HyperlinkGene Summary
Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM
Other Designations
Tryptophan oxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells.
Yuemei Zhao, Fengxing Tao, Jiayu Jiang, Lina Chen, Jizao Du, Xiaoxiao Cheng, Qin He, Shouhui Zhong, Wei Chen, Xiaoli Wu, Rongying Ou, Yunsheng Xu, Kai-Fu Tang.
Molecular MedicineRreports 2021 Jun; 23(6):445.
Application:WB-Ce, WB-Tr, Human, OVSAHO, T29, T29H cells.
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n-Butilydenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Rajamani K, Liu JW, Wu CH, Chiang IT, You DH, Lin SY, Hsieh DK, Lin SZ, Harn HJ, Chiou TW.
Neuropharmacology 2017 May; 117:434.
Application:WB-Ti, Mouse, Mouse cerebella.
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Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells.
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