TCF7L2 monoclonal antibody (M04), clone 1A9
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More Files
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Western Blot (Cell lysate)
TCF7L2 monoclonal antibody (M04), clone 1A9 Western Blot analysis of TCF7L2 expression in Hela S3 NE ( Cat # L013V3 ).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to TCF7L2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 1.5 ug/ml]
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TCF7L2.
Immunogen
TCF7L2 (AAH32656, 1 a.a. ~ 455 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPPNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
TCF7L2 monoclonal antibody (M04), clone 1A9 Western Blot analysis of TCF7L2 expression in Hela S3 NE ( Cat # L013V3 ).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to TCF7L2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 1.5 ug/ml]ELISA
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Gene Info — TCF7L2
Entrez GeneID
6934GeneBank Accession#
BC032656Protein Accession#
AAH32656Gene Name
TCF7L2
Gene Alias
TCF-4, TCF4
Gene Description
transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene Ontology
HyperlinkGene Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes
Other Designations
OTTHUMP00000020496|transcription factor 7-like 2
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Interactome
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Pathway
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Disease
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Publication Reference
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TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression.
Fuzheng Guo, Yan Wang.
Glia 2023 Feb; 71(2):143.
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Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.
Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH.
Genes & Development 2009 Jul; 23(13):1571.
Application：IHC, Mouse, CNS.
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TCF7L2 regulates late events in insulin secretion from pancreatic islet {beta}-cells.
da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.
Diabetes 2009 Apr; 58(4):894.
Application：WB-Ti, WB-Tr, Mouse, Rat, Islets, MIN6, INS-1 cells.
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TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression.
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