Western blot analysis of TCF7L2 over-expressed 293 cell line, cotransfected with TCF7L2 Validated Chimera RNAi ( Cat # H00006934-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TCF7L2 monoclonal antibody (M02), clone 1B1 (Cat # H00006934-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes