TAP2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TAP2 full-length
Host
Human
Theoretical MW (kDa)
75.7
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TAP2antibody (H00006891-D01P)byWesternBlots.
SDS-PAGE Gel
TAP2 transfected lysate.
Western Blot
Lane 1: TAP2 transfected lysate ( 75.7 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TAP2
Entrez GeneID
6891GeneBank Accession#
BC002751Protein Accession#
ENSP00000372599Gene Name
TAP2
Gene Alias
ABC18, ABCB3, APT2, D6S217E, PSF2, RING11
Gene Description
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq
Other Designations
ABC transporter, MHC 2|ATP-binding cassette, sub-family B (MDR/TAP), member 3|OTTHUMP00000029079|OTTHUMP00000038912|OTTHUMP00000038914|antigen peptide transporter 2|peptide supply factor 2|peptide transporter PSF2|transporter 2, ABC (ATP binding cassette)
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Alzheimer disease
- Arthritis
- Asthma
- Behcet Syndrome
- Bronchiectasis
- Bronchiolitis
- Brucellosis
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