TAF6 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TAF6 full-length
Host
Human
Theoretical MW (kDa)
74.58
Interspecies Antigen Sequence
Mouse (98); Rat (99)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TAF6 antibody (H00006878-B01) by Western Blots.
SDS-PAGE Gel
TAF6 transfected lysate.
Western Blot
Lane 1: TAF6 transfected lysate ( 74.58 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TAF6
Entrez GeneID
6878GeneBank Accession#
NM_005641.2Protein Accession#
-Gene Name
TAF6
Gene Alias
DKFZp781E21155, MGC:8964, TAF2E, TAFII70, TAFII80, TAFII85
Gene Description
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Omim ID
602955Gene Ontology
HyperlinkGene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. [provided by RefSeq
Other Designations
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kD|TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD|TBP-associated factor 6|transcription initiation factor TFIID 70 kD subunit
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Interactome
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Pathway
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