TAF6 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human TAF6 peptide using ARM Technology.
Immunogen
A synthetic peptide of human TAF6 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human TAF6 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — TAF6
Entrez GeneID
6878GeneBank Accession#
TAF6Gene Name
TAF6
Gene Alias
DKFZp781E21155, MGC:8964, TAF2E, TAFII70, TAFII80, TAFII85
Gene Description
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Omim ID
602955Gene Ontology
HyperlinkGene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. [provided by RefSeq
Other Designations
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kD|TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD|TBP-associated factor 6|transcription initiation factor TFIID 70 kD subunit
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Interactome
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Pathway
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