Western blot analysis of T over-expressed 293 cell line, cotransfected with T Validated Chimera RNAi ( Cat # H00006862-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with T monoclonal antibody (M01), clone 5H8 (Cat # H00006862-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq
OTTHUMP00000017588,T brachyury homolog,T brachyury-like,transcription factor T