Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

STAU1

Gene Alias

FLJ25010, STAU

Gene Description

staufen, RNA binding protein, homolog 1 (Drosophila)

Omim ID

Gene Ontology

Gene Summary

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq

Other Designations

OTTHUMP00000031233|OTTHUMP00000031234|OTTHUMP00000031235|OTTHUMP00000031236|OTTHUMP00000031238|staufen