ST14 monoclonal antibody (M05), clone 2F4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ST14.
Immunogen
ST14 (NP_068813, 298 a.a. ~ 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (79); Rat (79)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ST14 is approximately 1ng/ml as a capture antibody.ELISA
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Gene Info — ST14
Entrez GeneID
6768GeneBank Accession#
NM_021978Protein Accession#
NP_068813Gene Name
ST14
Gene Alias
HAI, MT-SP1, MTSP-1, MTSP1, PRSS14, SNC19, TADG-15
Gene Description
suppression of tumorigenicity 14 (colon carcinoma)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq
Other Designations
epithin|matriptase|membrane-type serine protease|serine protease TADG-15|suppression of tumorigenicity 14|suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)|tumor associated differentially expressed gene 15 protein
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Interactome
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Disease
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Publication Reference
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Novel surface targets and serum biomarkers from the ovarian cancer vasculature.
Sasaroli D, Gimotty PA, Pathak HB, Hammond R, Kougioumtzidou E, Katsaros D, Buckanovich R, Devarajan K, Sandaltzopoulos R, Godwin AK, Scholler N, Coukos G.
Cancer Biology & Therapy 2011 Aug; 12(3):169.
Application:IF, IHC, Human, Human ovarian cancer.
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Novel surface targets and serum biomarkers from the ovarian cancer vasculature.
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