Products

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ST14

Gene Alias

HAI, MT-SP1, MTSP-1, MTSP1, PRSS14, SNC19, TADG-15

Gene Description

suppression of tumorigenicity 14 (colon carcinoma)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq

Other Designations

epithin|matriptase|membrane-type serine protease|serine protease TADG-15|suppression of tumorigenicity 14|suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)|tumor associated differentially expressed gene 15 protein