ST5 monoclonal antibody (M01), clone 1A3
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ST5.
Immunogen
ST5 (NP_005409, 1038 a.a. ~ 1135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — ST5
Entrez GeneID
6764GeneBank Accession#
NM_005418Protein Accession#
NP_005409Gene Name
ST5
Gene Alias
DENND2B, HTS1, MGC33090, p126
Gene Description
suppression of tumorigenicity 5
Omim ID
140750Gene Ontology
HyperlinkGene Summary
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq
Other Designations
DENN/MADD domain containing 2B
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Interactome
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Disease
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